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Familial cyclic vomiting syndrome.

J Haan1, E E Kors, M D Ferrari

  • 1Department of Neurology, Leiden University Medical Centre, The Netherlands. jhaan@rijnland.nl

Cephalalgia : an International Journal of Headache
|September 17, 2002
PubMed
Summary

Pure cycling vomiting syndrome (CVS) may be hereditary. This study describes a family with four members affected by CVS without other symptoms, suggesting a genetic basis for this isolated condition.

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Area of Science:

  • Genetics
  • Neurology
  • Pediatrics

Background:

  • Cycling vomiting syndrome (CVS) is a rare disorder characterized by recurrent episodes of nausea and vomiting.
  • While some familial cases of CVS exist, most reported families include individuals with additional symptoms beyond CVS.
  • The etiology of isolated CVS remains largely unclear, with limited understanding of potential genetic predispositions.

Observation:

  • A family with four affected members exhibiting isolated cycling vomiting syndrome (CVS) is presented.
  • All affected individuals presented solely with CVS, lacking other associated neurological or gastrointestinal symptoms.
  • This observation contrasts with previously documented familial CVS cases that often involved comorbidities.

Findings:

  • The described family strongly suggests that 'pure' cycling vomiting syndrome, devoid of other symptoms, can be a hereditary disorder.
  • The pattern of inheritance within the family points towards a potential genetic transmission of isolated CVS.
  • This finding expands the known spectrum of CVS heritability.

Implications:

  • The identification of 'pure' CVS as a potentially hereditary condition necessitates further genetic research into its underlying mechanisms.
  • Understanding the genetic link may aid in developing targeted diagnostic and therapeutic strategies for affected families.
  • Further investigation into the relationship between hereditary isolated CVS and migraine is warranted, given their overlapping clinical features.

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