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Microbial transformation of hydrocortisone by Acremonium strictum PTCC 5282
Mohammad Ali Faramarzi1, Mojtaba Tabatabaei Yazdi, Abbas Shafiee
1Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, 14174, Tehran, Iran.
Steroids
|September 17, 2002
Abstract:
The ability of a genus of cephalosporium-like fungus isolated from soil, Acremonium strictum PTCC 5282, for hydrocortisone biotransformation has been investigated. This potential had not been previously examined. The fermentation yielded 11beta,17beta-dihydroxyandrost-4-en-3-one, 11beta,17alpha,20beta,21-tetrahydroxypregn-4-en-3-one and 21-acetoxy-11beta,17alpha,20-trihydroxypregn-4-en-3-one. Each microbial metabolite was purified and characterized using spectroscopic methods.