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[Heerfordt syndrome].

Noriaki Takahashi1, Takashi Horie

  • 1First Department of Internal Medicine, Nihon University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 18, 2002
PubMed
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Heerfordt syndrome, a rare condition causing fever, uveitis, and facial nerve palsy, predominantly affects women aged 20-40. Diagnosis involves histology, 67 gallium scans, and treatment with prednisolone may be needed for facial palsy.

Area of Science:

  • Ophthalmology
  • Neurology
  • Rheumatology

Context:

  • Heerfordt syndrome, a rare manifestation of sarcoidosis, presents with fever, uveitis, parotid gland swelling, and facial nerve palsy.
  • A review of 53 reported cases in Japan up to 2000 highlights key demographic and clinical features.

Purpose:

  • To review and summarize clinical cases of Heerfordt syndrome reported in Japan.
  • To consolidate information on the epidemiology, diagnosis, and management of Heerfordt syndrome.

Summary:

  • The syndrome predominantly affects females aged 20-40.
  • Histological confirmation of sarcoidosis is definitive for diagnosis.
  • Diagnostic tools include 67 gallium scans showing characteristic uptake in ophthalmic, parotid, and hilar lesions.

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  • Prednisolone therapy is often indicated, particularly for managing facial palsy.

    • Impact:

    • Provides a comprehensive overview of Heerfordt syndrome cases in Japan, aiding clinicians in diagnosis and management.
    • Highlights the importance of a multidisciplinary approach involving ophthalmology, neurology, and rheumatology.
    • Emphasizes the utility of specific diagnostic modalities and therapeutic interventions for this rare condition.