Related Experiment Video
Updated: Aug 17, 2026
Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets
Published on: March 12, 2019
Carbon-11 labeled radioligands for imaging brain cannabinoid receptors
William B Mathews1, Ursula Scheffel, Paige A Rauseo
1Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA. bmathews@petscan.nm.jhu.edu
Abstract:
Two radioligands, [(11)C] SR149080 and its morpholino analog [(11)C] SR149568, were synthesized by reaction of the respective phenolic precursors with [(11)C] methyl iodide. Both radioligands had appropriate regional brain distribution for cannabinoid receptors in mice with peak target to non-target ratios of 2.2 for [(11)C] SR149080 and 1.6 for [(11)C] SR149568 at 90 and 30 minutes post-injection respectively. The uptake of both tracers was blocked with a 1 mg/kg dose of SR141716A.
