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Cationic complex: (99m)Tc-N,N'-dimethyldiaminedithiol.

Jae Min Jeong¹, Yun-Sang Lee, Young Joo Kim

¹Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea. jmjng@snu.ac.kr

Nuclear Medicine and Biology

|September 18, 2002

Summary

Technetium-99m-N,N'-dimethyl-diaminedithiol exhibits unexpected positive charge and low lipophilicity. Biodistribution indicates bile excretion and potential for myocardial imaging, differing from typical brain imaging agents.

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Area of Science:

Radiochemistry
Nuclear Medicine
Pharmacology

Background:

Diaminedithiol (DADT) derivatives are typically neutral and lipophilic, forming technetium chelates for brain imaging.
Previous research established DADT compounds as effective brain imaging agents due to their lipophilic neutral chelate formation with technetium.

Purpose of the Study:

To characterize the physicochemical properties and biodistribution of technetium-99m-N,N"-dimethyl-diaminedithiol (99mTc-N,N"-dimethylDADT).
To evaluate the potential of 99mTc-N,N"-dimethylDADT as a diagnostic imaging agent.

Main Methods:

Synthesis and characterization of 99mTc-N,N"-dimethylDADT.
Determination of lipophilicity (log P).
In vivo biodistribution studies in mice.

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Main Results:

99mTc-N,N"-dimethylDADT was found to possess a positive charge and low lipophilicity (log P = 0.1).
Biodistribution studies revealed significant accumulation in the intestine at 1 hour post-injection, indicating bile excretion.
Elevated uptake in the heart was observed in mice.

Conclusions:

99mTc-N,N"-dimethylDADT deviates from the expected properties of DADT derivatives, exhibiting a positive charge and low lipophilicity.
The observed biodistribution pattern, particularly bile excretion and increased heart uptake, suggests potential applications for myocardial imaging rather than brain imaging.