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Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis
S H Marshall1, C J Donskey, R Hutton-Thomas
1Research and Medical Services, Department of Veterans Affairs Medical Center and Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Antimicrobial Agents and Chemotherapy
|September 18, 2002
Abstract:
Resistance to linezolid has been associated with a G2576U mutation in domain V of the 23S rRNA. We analyzed nine clinical isolates of linezolid-resistant enterococci and showed a clear association between the number of 23S rRNA genes containing this mutation and the level of linezolid resistance expressed.