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Action of Rubus coreanus extract on systemic and local anaphylaxis
Tae-Yong Shin1, Sang-Hyun Kim, Eun-Soon Lee
1College of Pharmacy, Woosuk University, Chonju, Chonbuk, 565-701, Republic of Korea. tyshin@core.woosuk.ac.kr
Phytotherapy Research : PTR
|September 19, 2002
Summary
The aqueous extract of Rubus coreanus Miq. fruits (RCAE) effectively reduced anaphylaxis symptoms in mice and inhibited histamine release from mast cells. This suggests RCAE has significant antianaphylactic properties.
Area of Science:
- Pharmacology
- Immunology
- Natural Products Chemistry
Background:
- Anaphylaxis is a severe allergic reaction.
- Natural compounds are explored for therapeutic potential.
- Rubus coreanus Miq. fruits are traditionally used.
Purpose of the Study:
- To investigate the antianaphylactic effects of Rubus coreanus Miq. fruit extract (RCAE).
- To determine the mechanisms underlying RCAE's action on anaphylaxis.
Main Methods:
- Systemic and local anaphylaxis models in mice were used.
- Rat peritoneal mast cells (RPMC) were utilized for in vitro studies.
- Histamine release, cAMP levels, and TNF-α production were measured.
Main Results:
- RCAE dose-dependently inhibited compound 48/80-induced systemic anaphylaxis.
- RCAE suppressed anti-DNP IgE-induced local anaphylaxis and histamine release from RPMC.
- RCAE increased cAMP levels and inhibited TNF-α production in RPMC.
Conclusions:
- RCAE exhibits significant antianaphylactic activity.
- The mechanism involves inhibition of histamine and TNF-α release.
- RCAE shows potential as a therapeutic agent for allergic reactions.