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Prolonged parenteral nutrition after neonatal gastrointestinal surgery. A Danish experience
Anne Estmann Christensen1, Niels Qvist, Steffen Husby
1Department of Paediatrics, Odense University Hospital, DK-5000 Odense C, Denmark.
Insights
Long-term parenteral nutrition (PN) is essential for infants after neonatal gastrointestinal surgery. This study found a low incidence of prolonged PN need, primarily due to gastroschisis and intestinal atresia, with short gut syndrome infants requiring longer treatment.
Area of Science:
- Neonatal surgery
- Pediatric gastroenterology
- Clinical nutrition
Background:
- Long-term parenteral nutrition (PN) is critical for infant survival post-neonatal gastrointestinal surgery.
- Population-based studies are needed to assess PN requirements and patient characteristics.
Purpose of the Study:
- To estimate the incidence of long-term PN in infants with gastrointestinal disease in Western Denmark.
- To characterize these infants by diagnosis and clinical course.
Main Methods:
- Retrospective review of infants with gastrointestinal disease requiring prolonged PN (≥55 days) over 11.5 years.
- Analysis of diagnoses, clinical course, hospital stay, and outcomes.
Main Results:
- Low incidence of long-term PN (6.1 per 10^5 births/year).
- Gastroschisis and intestinal atresia were most common diagnoses.
- Short gut syndrome (n=6) had longer hospital stays and PN duration compared to others (n=15).
- Short bowel syndrome incidence was 1.7 per 10^5 births/year.
Conclusions:
- Prolonged PN is infrequent in infants after gastrointestinal surgery.
- Gastroschisis and intestinal atresia are primary causes.
- Clinical course involves catheter issues and sepsis; mortality was 14%.
Introduction:
Long-term treatment with parenteral nutrition (PN) may be essential for survival in infants after neonatal gastrointestinal surgery. It seemed well indicated in a population-based study to estimate the need for long-term PN and to characterize the infants that received TPN with regard to diagnosis and clinical course.
Methodology:
This study reviews the clinical course of infants with gastrointestinal disease (gastroschisis, intestinal atresia, omphalocele, volvulus, Hirschsprung's disease and necrotizing enterocolitis) with a prolonged need for parenteral nutrition in the Western part of Denmark over a period of 11 1/2 years.
Results:
A total of 21 patients with need for PN for 55 days or more due to gastrointestinal disease were registered with a cumulative hospital stay of 4462 days. The study showed a low incidence of long-term PN due to gastro-intestinal surgical illness with an incidence of approx 6.1 per 10(5) births per year. Gastroschisis and intestinal atresia were the most common primary diagnoses. Two groups of patients were identified: 1) six infants with short gut syndrome caused by major resections or atresia of the small intestine (less than 50 cm intestine) and 2) a larger group (n = 15) with no or only minor resection of the small bowel. The former group had a significantly longer hospital stay and a longer need for PN. The incidence of short bowel syndrome including six infants was 1.7 per 10(5) births per year.
Conclusions:
Prolonged need for PN in infants operated for gastrointestinal disease was registered at a low frequency in the Western part of Denmark, most frequently caused by gastroschisis and intestinal atresia. The clinical course was characterized by repetitive problems of catheter replacements and septic episodes. The mortality due to conditions related to the gastrointestinal disease was 14% (3/21).