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Changes in fibrinogen level in liver cirrhosis
Saatea Arif1, A Sattar Khan, Arif Raza Khan
1Department of Biochemistry, Khyber Medical College, University of Peshawar, Pakistan.
Journal of Ayub Medical College, Abbottabad : JAMC
|September 20, 2002
Summary
Low fibrinogen levels are linked to liver cirrhosis, aiding in early diagnosis and prognosis. This study highlights fibrinogen as a potential biomarker for managing cirrhosis complications and bleeding risks.
Area of Science:
- Hepatology
- Clinical Biochemistry
- Hematology
Background:
- Liver cirrhosis is a major cause of illness and death.
- Early diagnosis of liver cirrhosis is crucial for preventing complications and improving patient outcomes.
- Fibrinogen level estimation may help predict and prevent bleeding tendencies in cirrhosis patients.
Purpose of the Study:
- To determine plasma fibrinogen levels in liver cirrhosis patients.
- To compare fibrinogen levels between cirrhosis patients and healthy controls.
- To establish fibrinogen as a diagnostic and prognostic marker for liver cirrhosis.
Main Methods:
- Plasma fibrinogen levels were measured in 82 patients with confirmed liver cirrhosis (aged 18-60).
- A comparison was made between patient fibrinogen levels and those of normal controls.
- Fibrinogen levels were quantified using the Fibriprest-2 assay.
Main Results:
- Patients with liver cirrhosis exhibited significantly lower fibrinogen levels compared to controls.
- Approximately 40% of cirrhosis cases presented with low fibrinogen levels.
- Nearly 44% of cirrhosis patients had normal fibrinogen levels.
Conclusions:
- Fibrinogen levels were found to be low in both early and terminal stages of liver cirrhosis.
- Advancing cirrhosis showed higher fibrinogen levels relative to controls, which maintained normal levels.
- Fibrinogen levels demonstrate potential as a biomarker for assessing the stage and prognosis of liver cirrhosis.