Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rhinologic changes in Wegener's granulomatosis.

Glyn Lloyd1, Valerie J Lund, Tim Beale

  • 1Royal National Throat, Nose and Ear Hospital, London, UK.

The Journal of Laryngology and Otology
|September 20, 2002
PubMed
Summary

Imaging findings in sinonasal Wegener's granulomatosis can aid diagnosis. CT and MRI reveal bone destruction and new bone formation, crucial for identifying this condition, especially in localized cases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Remission in Global Airway Diseases: EUFOREA Consensus Paper.

Allergy·2026
Same author

Multidisciplinary Consensus Statement for Appropriate Evaluation and Workup of Sinonasal Masses.

JAMA otolaryngology-- head & neck surgery·2026
Same author

Distinct H3K27 Methylation States Drive Cellular Responses to the Histone Demethylase Inhibitor GSK-J4 in Ovarian Cancer Cells.

Molecular cancer therapeutics·2026
Same author

Outcomes of different treatment patterns for adenoid cystic carcinoma of the anterior craniofacial area: A multi-institutional study on 578 patients.

European journal of cancer (Oxford, England : 1990)·2026
Same author

Distinct H3K27 methylation states drive cellular responses to the histone demethylase inhibitor GSK-J4 in ovarian cancer cells.

Molecular cancer therapeutics·2026
Same author

Operationalising reproducibility in soft robotics.

Frontiers in robotics and AI·2026

Area of Science:

  • Radiology
  • Otolaryngology
  • Immunology

Background:

  • Sinonasal Wegener's granulomatosis presents diagnostic challenges.
  • Distinguishing localized from systemic forms is clinically important.
  • Imaging plays a key role in diagnosis.

Purpose of the Study:

  • To evaluate the diagnostic utility of CT and MRI in sinonasal Wegener's granulomatosis.
  • To identify characteristic imaging features.
  • To correlate imaging findings with clinical presentation.

Main Methods:

  • Retrospective review of CT and MRI scans from 28 patients with sinonasal Wegener's granulomatosis (1990-2001).
  • Evaluation by a panel of one otolaryngologist and two radiologists.
  • Analysis of imaging findings including mucosal thickening, bone destruction, and new bone formation.

Related Experiment Videos

Main Results:

  • 85.7% showed mucosal thickening.
  • 75% demonstrated bone destruction.
  • 50% exhibited new bone formation.
  • Orbital involvement occurred in 30% of patients.
  • CT findings of bone destruction and new bone formation, especially with MRI fat signal, are highly suggestive of Wegener's.

Conclusions:

  • CT and MRI can reveal characteristic features of sinonasal Wegener's granulomatosis.
  • Imaging is vital for diagnosing localized disease where clinical signs and cANCA tests may be inconclusive.
  • Specific imaging patterns aid in differentiating Wegener's from other sinonasal conditions.