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Related Experiment Videos

Scopolamine effects on delayed spatial alternation in the rat.

G A Heise, B Hrabrich, N L Lilie

    Pharmacology, Biochemistry, and Behavior
    |November 1, 1975
    PubMed
    Summary

    Scopolamine did not impair rats

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    Area of Science:

    • Behavioral Neuroscience
    • Cognitive Psychology

    Background:

    • Delayed alternation tasks assess working memory.
    • Scopolamine is an anticholinergic drug affecting cognition.

    Purpose of the Study:

    • Investigate scopolamine's effects on delayed alternation in rats.
    • Determine if scopolamine impairs stimulus discrimination or response control.

    Main Methods:

    • Rats trained on a delayed alternation task.
    • Administered scopolamine and assessed error rates.
    • Manipulated external stimuli control.

    Main Results:

    • Scopolamine did not increase perseveration or errors on correction trials.
    • Performance was unaffected when external stimuli controlled alternation.
    • Delayed alternation was impaired, suggesting a deficit in stimulus discrimination.

    Conclusions:

    • Scopolamine disrupts delayed alternation performance.
    • The deficit is likely due to impaired stimulus discrimination, not perseveration.
    • Cognitive control by non-present stimuli is affected by scopolamine.

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