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Updated: Sep 29, 2026

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Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis
Published on: July 8, 2025
Linear dichroism for the detection of single base pair mutations
D J Halsall1, A Rodger, T R Dafforn
1Department of Clinical Biochemistry, Addenbrooke's Hospital, Hills Rd, Cambridge, UK CB2 2XY.
Abstract:
Flow linear dichroism is shown to be able to detect single base mismatches in a polymerase chain reaction (PCR) amplimers from exon 10 of the human beta-glucocerebrosidase gene (associated with Gaucher disease) over a kilobase long with no post PCR manipulation.

