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Locked Nucleic Acid Flow Cytometry-fluorescence in situ Hybridization (LNA flow-FISH): a Method for Bacterial Small RNA Detection
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Universal hybridization using LNA (locked nucleic acid) containing a novel pyrene LNA nucleotide monomer

B R Babu1, J Wengel

  • 1Department of Chemistry, University of Southern Denmark, DK-5230 Odense M, Denmark.

Chemical Communications (Cambridge, England)
|September 21, 2002
PubMed

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Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...