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Virus in Trichomonas--an ultrastructural study.

Marlene Benchimol¹, Sandra Monteiro, T-H Chang

¹Universidade Santa Ursula, Rua Jornalista Orlando Dantas, 59, Botafogo, 22231-010, Rio de Janeiro, Brazil. marlene@usu.br

Parasitology International

|September 24, 2002

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Trichomonas vaginalis can host multiple double-stranded RNA viruses, not just one. This study reveals a diverse viral population and their infection pathway within the parasite.

Area of Science:

Microbiology
Virology
Cell Biology

Background:

Trichomonas vaginalis is a common human urogenital parasite.
Most T. vaginalis isolates harbor a single type of 33 nm icosahedral dsRNA virus.
Previous research characterized T. vaginalis viruses as a homogeneous population.

Purpose of the Study:

To investigate the viral population in T. vaginalis isolate 347.
To characterize the morphology and behavior of T. vaginalis viruses (TVV).
To elucidate the infection route and cytopathology of TVV in T. vaginalis.

Main Methods:

Electron microscopy of purified virus fractions and parasite thin sections.
Negative staining carbon-film method for virus visualization.
Transfection of purified VLPs into virus-free T. vaginalis isolates.

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Main Results:

A heterogeneous population of T. vaginalis viruses (33-200 nm, various shapes) was identified.
Viruses were observed associated with the Golgi complex and budding from it.
TVV were shown to enter T. vaginalis via endocytosis and affect cellular structures, leading to cell lysis or clustering.

Conclusions:

T. vaginalis can be simultaneously infected with multiple dsRNA viruses.
T. vaginalis may serve as a reservoir for diverse viruses.
The study details TVV entry, intracellular trafficking, and cytopathic effects, including Golgi alterations.