Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Missing mass effect in biosensor's QCM applications.

M V Voinova1, M Jonson, B Kasemo

  • 1Department of Applied Physics, Chalmers University of Technology and Göteborg University, S-412 96, Göteborg, Sweden. voinova@fy.chalmers.se

Biosensors & Bioelectronics
|September 24, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Magnetoconductance Anisotropies and Aharonov-Casher Phases.

Physical review letters·2022
Same author

Epidemiology of suicidal feelings in an ageing Swedish population: from old to very old age in the Gothenburg H70 Birth Cohort Studies.

Epidemiology and psychiatric sciences·2019
Same author

Ferritin-supported lipid bilayers for triggering the endothelial cell response.

Colloids and surfaces. B, Biointerfaces·2016
Same author

Spin-mediated Photomechanical Coupling of a Nanoelectromechanical Shuttle.

Physical review letters·2016
Same author

Rashba Splitting of Cooper Pairs.

Physical review letters·2016
Same author

Single-electron shuttle based on electron spin.

Physical review letters·2014
Same journal

Recent developments of textile-based triboelectric nanogenerators for smart sports applications.

Biosensors & bioelectronics·2026
Same journal

One-Tube RPA-CRISPR-Cas13a assay with rational design for single-molecule detection of waterborne viruses in drinking water treatment.

Biosensors & bioelectronics·2026
Same journal

AI-driven photophysics-aware design of fluorescent probes with applications in α-synuclein biosensing and inhibitor screening.

Biosensors & bioelectronics·2026
Same journal

Three-dimensional helical integration of high-density linear microelectrode arrays and their cross-tissue applications.

Biosensors & bioelectronics·2026
Same journal

Integration of electrochemical sensors in organ-on-a-chip microfluidic platforms: Advances and perspectives.

Biosensors & bioelectronics·2026
Same journal

DNN-PURE: A deep neural network approach to paper-based urea sensing.

Biosensors & bioelectronics·2026
See all related articles

Quartz Crystal Microbalance (QCM) in liquid applications shows deviations from ideal mass response due to viscoelasticity. A new theory provides an analog of the Sauerbrey relation for accurate biosensing in biofluids.

Area of Science:

  • Biophysics
  • Materials Science
  • Analytical Chemistry

Background:

  • Quartz Crystal Microbalance (QCM) enables in situ studies of biomaterials like proteins and cells in liquid.
  • Viscoelastic properties of adsorbed biomaterials cause deviations from the Sauerbrey relation, limiting biosensing accuracy.
  • Understanding these deviations is crucial for reliable QCM applications in biofluids.

Purpose of the Study:

  • To develop a rigorous theoretical analysis explaining the deviation from ideal mass response in QCM measurements of soft overlayers in liquid.
  • To derive an analog of the Sauerbrey relation applicable to layered viscous/viscoelastic media.
  • To enable accurate physical interpretation of QCM experimental data for surface mass measurements in biofluids.

Main Methods:

Related Experiment Videos

  • Theoretical analysis of QCM response for soft overlayers in contact with liquid.
  • Development of an analog of the Sauerbrey relation for layered viscous/viscoelastic media.
  • Comparison of theoretical predictions with experimental QCM data from supported membranes.

    • Main Results:

    • A rigorous theoretical framework explaining the deviation from the ideal Sauerbrey relation for soft overlayers in liquid was established.
    • An analog of the Sauerbrey relation for layered viscous/viscoelastic media was derived, allowing for correct interpretation of QCM data.
    • A novel physical effect termed 'missing mass' in liquid phase measurements was predicted.
    • Theoretical results were validated against experimental QCM measurements on supported membranes.

    Conclusions:

    • The developed theory accurately explains deviations in QCM measurements due to viscoelasticity in liquid.
    • The derived analog of the Sauerbrey relation is essential for precise surface mass determination of biomolecular films in biofluids.
    • The 'missing mass' effect highlights a critical consideration for interpreting QCM data in liquid phase biosensing.
    • This work enhances the reliability and applicability of QCM for in situ biosensing in complex biological media.