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Thyroid hormones and lymphoid cells.

G Lundell, H Blomgren

    Acta Radiologica: Therapy, Physics, Biology
    |December 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Thyroid hormones, including triiodothyronine and thyroxine, stimulate DNA synthesis in human lymphoid cells. Both D- and L-forms of these hormones, in racemic mixtures, increased DNA synthesis in vitro.

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    Area of Science:

    • Endocrinology
    • Molecular Biology
    • Cell Biology

    Background:

    • Thyroid hormones are crucial regulators of cellular metabolism and development.
    • The specific effects of different stereoisomers of thyroid hormones on human lymphoid cells require further elucidation.

    Purpose of the Study:

    • To investigate the in vitro impact of D- and L-forms of triiodothyronine and thyroxine on DNA synthesis in human lymphoid cells.
    • To determine if stereoisomerism affects the hormonal influence on DNA replication.

    Main Methods:

    • Human lymphoid cells were cultured in vitro.
    • The incorporation of 14C-thymidine into cellular DNA was measured.
    • Cells were treated with varying concentrations of D- and L-thyroxine and triiodothyronine, including racemic mixtures.

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    Main Results:

    • Both D- and L-forms of triiodothyronine and thyroxine significantly increased 14C-thymidine incorporation into DNA.
    • The stimulatory effect on DNA synthesis was observed with large quantities of the hormones, irrespective of their isomeric form (racemic).

    Conclusions:

    • Thyroid hormones, regardless of stereoisomer configuration, can stimulate DNA synthesis in human lymphoid cells.
    • These findings suggest a conserved mechanism for thyroid hormone action on DNA replication in lymphoid cells, irrespective of D- or L-configuration.