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Mineral deposits formation in bioactive IUD's
Advances in Contraceptive Delivery Systems : CDS
|January 1, 1987
Summary
Mineral organic deposits form on all intrauterine devices (IUDs), increasing with time. These deposits, primarily protein, sodium, and calcium, vary based on IUD type, with inert IUDs showing the highest accumulation.
Area of Science:
- Biomaterials Science
- Gynecology
- Materials Science
Background:
- Mineral organic deposits are known to form on inert intrauterine devices (IUDs).
- Understanding deposit formation on bioactive IUDs is crucial for assessing long-term performance and biocompatibility.
Purpose of the Study:
- To investigate the presence and composition of mineral organic deposits on various types of IUDs.
- To analyze how deposit formation varies with IUD type and duration of use.
Main Methods:
- Inert, progesterone-releasing, and copper-releasing IUDs were retrieved after 12, 24, and 36 months.
- Devices were dissected, and organic material was removed. Remaining material was extracted using hydrochloric acid and sodium hydroxide.
- Protein and inorganic ion content (sodium, calcium) in the deposits were quantified.
Main Results:
- Mineral organic deposits were observed on all tested IUD types.
- Deposit accumulation increased over time in utero, following a device-specific pattern.
- Inert Lippes Loop D showed the highest deposit levels (proteins, calcium, sodium), followed by copper IUDs, and then progesterone-releasing IUDs.
Conclusions:
- All types of intrauterine devices are susceptible to mineral organic deposit formation.
- The extent of deposit formation is dependent on the IUD material and its duration of placement.
- These findings have implications for understanding IUD longevity and potential biological interactions.
Keywords:
CalciumContraceptionContraceptive Methods--analysisContraceptive Methods--pharmacodynamicsExaminations And DiagnosesFamily PlanningIngredients And ChemicalsIud, Copper ReleasingIud, Hormone ReleasingIud, UnmedicatedIud--analysisIud--pharmacodynamicsLaboratory Examinations And DiagnosesLaboratory ProceduresOrganic ChemicalsProteinsSodium