Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Solid-phase synthesis and bioevaluation of lupeol-based libraries as antimalarial agents.

T Srinivasan1, G K Srivastava, A Pathak

  • 1Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India.

Bioorganic & Medicinal Chemistry Letters
|September 25, 2002
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Test of CP Symmetry in the Neutral Decays of Λ via J/ψ→ΛΛ[over ¯].

Physical review letters·2026
Same author

Precise Measurement of the Chromoelectric Dipole Moment of the Charm Quark.

Physical review letters·2026
Same author

Precise Measurement of Matter-Antimatter Asymmetry with Entangled Hyperon-Antihyperon Pairs.

Physical review letters·2026
Same author

Search for Light Pseudoscalar Bosons, Pair-Produced in Higgs Boson Decays in the Four-Electron Final State in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

First Evidence for Mixing-Induced CP Violation in B_{s}^{0}→J/ψϕ(1020) Decays in pp Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

Observation of Λ[over ¯]p→K^{+}π^{+}π^{-}π^{0} and Λ[over ¯]p→K^{+}π^{+}π^{-}2π^{0}.

Physical review letters·2026

This study describes synthesizing lupeol-based compound libraries using solid-phase synthesis. A library of lupeol derivatives was screened for antimalarial activity against Plasmodium falciparum.

Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis
  • Parasitology

Background:

  • Lupeol, a natural triterpenoid, has potential biological activities.
  • Developing efficient synthetic routes for lupeol derivatives is crucial for drug discovery.
  • Solid-phase synthesis offers advantages for library generation and diversification.

Purpose of the Study:

  • To develop a solid-phase synthesis strategy for generating diverse lupeol-based compound libraries.
  • To create key intermediates for disubstituted lupeol derivatives.
  • To screen the synthesized library for in-vitro antimalarial activity.

Main Methods:

  • Anchoring lupeol to a solid support (Rink amide/Sieber Amide) via dicarboxylic acid linkers.
  • Generating polymer-linked intermediates: 3beta-O-(resin-alkanoyl)-lup-20(29)-ene and its bromo/amino derivatives.

Related Experiment Videos

  • Synthesizing a 96-member library of disubstituted lupeol derivatives.
  • Screening the library against Plasmodium falciparum in vitro.

    • Main Results:

    • Successful synthesis of polymer-linked lupeol intermediates.
    • Generation of a diverse library of lupeol derivatives.
    • Identification of potential antimalarial compounds within the library (specific activity data not detailed in abstract).

    Conclusions:

    • The described solid-phase approach is effective for synthesizing lupeol-based libraries.
    • This methodology facilitates the exploration of lupeol derivatives for antimalarial drug discovery.
    • Further studies are warranted to optimize active compounds and elucidate their mechanism of action.