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Benzodiazepine inhibitors of the MMPs and TACE
Frances C Nelson1, Efren Delos Santos, Jeremy I Levin
1Wyeth Research, 401N. Middletown Road, Pearl River, NY 10965, USA. nelson@wyeth.com
Bioorganic & Medicinal Chemistry Letters
|September 25, 2002
Abstract:
A series of benzodiazepine inhibitors of the MMPs and TACE has been developed. These compounds display an interesting selectivity profile and should be useful tools for exploring the biological relevance of such selectivity.