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Olanzapine-induced hyperventilation: case report.

S Pirzada Sattar1, David R Gastfriend

  • 1Creighton University School of Medicine, Department of Psychiatry, 3528 Dodge St., Omaha, NE, USA. shrink@prodigy.net

Journal of Psychiatry & Neuroscience : JPN
|September 26, 2002
PubMed
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Olanzapine, an atypical antipsychotic, is linked to fewer movement disorders but can cause other side effects. This case study reports a new potential side effect: hyperventilation in a patient undergoing olanzapine therapy.

Area of Science:

  • Pharmacology
  • Clinical Psychiatry

Background:

  • Olanzapine is an atypical antipsychotic medication.
  • While generally associated with fewer extrapyramidal side effects than older antipsychotics, olanzapine has a known side effect profile.
  • Reported adverse events include dystonia, tardive dyskinesia, hypotension, diabetes mellitus, seizures, and neuroleptic malignant syndrome.

Observation:

  • A case of a male patient experiencing dyspnea and hyperventilation during olanzapine therapy is presented.
  • This represents a previously unreported association in published literature.

Findings:

  • The patient developed symptoms of dyspnea and hyperventilation.
  • These symptoms occurred in the context of olanzapine treatment.

Implications:

Related Experiment Videos

  • This case suggests hyperventilation may be a potential, albeit rare, adverse effect of olanzapine.
  • Clinicians should be aware of this possible association when treating patients with olanzapine.
  • Further investigation may be warranted to understand the mechanism and frequency of this side effect.