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Drug eruption in a dog.

B B Baker, A A Stannard

    Journal of the American Veterinary Medical Association
    |March 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    A Vizsla dog experienced recurrent dermatitis after acepromazine injections. This suggests a potential adverse drug reaction to the tranquilizer in susceptible dogs, requiring careful monitoring.

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    Area of Science:

    • Veterinary Dermatology
    • Pharmacology
    • Canine Medicine

    Background:

    • Acepromazine is a phenothiazine derivative commonly used as a tranquilizer and antiemetic in veterinary medicine.
    • Adverse drug reactions can occur in animals, manifesting in various clinical signs.
    • Dermatological conditions in dogs can have diverse etiologies, including allergic or hypersensitivity reactions.

    Purpose of the Study:

    • To report a case of recurrent dermatitis in a dog following parenteral administration of acepromazine.
    • To highlight the potential for acepromazine to induce dermatological adverse effects.
    • To contribute to the understanding of drug-induced skin reactions in canines.

    Main Methods:

    • A case study involving a young adult Vizsla dog.

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  • Observation of clinical signs and patient history following acepromazine administration.
  • Assessment of treatment response and recurrence of symptoms.

    • Main Results:

    • The dog developed scaly, erythematous dermatitis after parenteral acepromazine.
    • Symptoms resolved with symptomatic treatment (water baths).
    • Dermatitis recurred approximately 4 months later, coinciding with subsequent acepromazine administration.

    Conclusions:

    • Recurrent dermatitis in this Vizsla was potentially linked to parenteral acepromazine administration.
    • This case suggests a possible hypersensitivity or idiosyncratic reaction to acepromazine in some dogs.
    • Veterinarians should consider acepromazine as a potential cause of dermatitis in dogs with compatible clinical histories.