Related Experiment Video
Updated: Sep 29, 2026

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes
Published on: May 31, 2018
Recombinant glucocorticoid induced tumour necrosis factor receptor (rGITR) induced COX-2 activity in murine
Hyun-Hee Shin1, Byoung S Kwon, Hye-Seon Choi
1Department of Biological Sciences and the Immunomodulation Research Center, University of Ulsan, Ulsan, Korea.
Abstract:
Stimulation of murine macrophages with recombinant soluble glucocorticoid induced tumour necrosis factor receptor (GITR) induced cyclooxygenase (COX)-2 protein and generated significant amounts of PGE(2). Previous result demonstrated that macrophages express GITR and GITR ligand constitutively. Induction of COX-2 was synergistic with interferon (INF)-gamma. GITR/ligand system could deliver an activation signal to macrophages in inflammatory processes.