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Programmed death in yeast as adaptation?

Vladimir P Skulachev1

  • 1Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russia. skulach@belozersky.msu.ru

FEBS Letters
|September 26, 2002
PubMed
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Yeast programmed cell death, or apoptosis, is directly supported by new findings. A specific caspase activated by hydrogen peroxide or aging, and pheromone-induced cell death requiring specific cellular components, have been identified.

Area of Science:

  • * Molecular Biology
  • * Cell Biology
  • * Genetics

Background:

  • * Indirect evidence suggested programmed cell death (apoptosis) in yeast.
  • * Mammalian apoptotic proteins and toxic compounds influenced yeast viability.
  • * Observed yeast death exhibited apoptotic markers.

Purpose of the Study:

  • * To provide direct evidence for programmed cell death in yeast.
  • * To identify specific molecular mechanisms underlying yeast apoptosis.
  • * To investigate the role of pheromones in yeast cell fate.

Main Methods:

  • * Identification of a caspase activated by hydrogen peroxide and aging.
  • * Analysis of yeast death induced by high pheromone levels.
  • * Investigation of the role of mitochondrial DNA, cytochrome c, and protein kinase cascades.

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Main Results:

  • * A caspase crucial for protein synthesis-dependent yeast death was identified.
  • * Pheromone-induced yeast death was found to be programmed, requiring specific cellular components.
  • * Yeast cells failing to mate were eliminated by pheromones, favoring sexual reproduction.

Conclusions:

  • * Specific apoptosis-mediating proteins exist in Saccharomyces cerevisiae.
  • * Pheromones regulate yeast cell death to promote mating and generational turnover.
  • * Programmed cell death in yeast may enhance adaptation to adverse conditions.