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Early events in atopy.

Hugo P Van Bever1

  • 1Department of Paediatrics, National University Singapore, 5 Lower Kent Ridge Road, 119075 Singapore. paevbhps@nus.edu.sg

European Journal of Pediatrics
|September 26, 2002
PubMed
Summary
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Early identification of allergy markers, like elevated IgE in cord blood, enables timely prevention strategies for allergic diseases. This proactive approach can mitigate the impact of environmental factors and T-helper imbalances.

Area of Science:

  • Immunology
  • Allergy Research
  • Pediatric Health

Background:

  • Rising prevalence of allergic diseases (asthma, rhinitis, dermatitis) linked to T-helper (Th1-Th2) imbalance.
  • Decreased microbial exposure and increased allergen exposure (house dust mite) promote Th2 responses.
  • T-helper lymphocyte imbalance is a key factor in the increasing incidence of allergic conditions.

Purpose of the Study:

  • To highlight the importance of early allergy marker identification.
  • To discuss primary prevention strategies for at-risk newborns.
  • To explore the potential of early interventions in managing allergic disease development.

Main Methods:

  • Review of factors contributing to allergic disease prevalence.
  • Analysis of early allergy markers, including total IgE in cord blood.

Related Experiment Videos

  • Evaluation of primary prevention measures like allergen and pollution avoidance.

    • Main Results:

    • Increased total IgE in cord blood serves as an early marker for allergy risk.
    • Primary prevention focuses on minimizing early allergen and pollutant exposure.
    • Early use of cetirizine shows potential in preventing or delaying asthma in children with atopic eczema.

    Conclusions:

    • Identification of atopic newborns is now feasible.
    • Adequate early prevention strategies can be implemented for at-risk infants.
    • Proactive intervention can significantly impact the trajectory of allergic disease development.