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Stereostructure of a novel cytotoxic 18-membered macrolactone antibiotic FD-891
Tadashi Eguchi1, Kayako Kobayashi, Hidehiro Uekusa
1Department of Chemistry and Materials Science, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo 152-8551, Japan. eguchi@cms.titech.ac.jp
Organic Letters
|September 27, 2002
Abstract:
The absolute stereochemistry of FD-891, a novel cytotoxic 18-membered macrolactone antibiotic, was determined by a synthetic approach as well as X-ray diffraction of degradative derivatives. The absolute configuration of FD-891 turned out to be as shown above. The stable conformer of FD-891 was also discussed with respect to biological activity by comparison with the structurally related concanamycin A on the bases of molecular mechanics calculations. [structure: see text]