Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diabetes trends in Japan.

Ryuzo Kawamori1

  • 1Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Hongo, Tokyo, Japan. kawamori@med.juntendo.ac.jp

Diabetes/Metabolism Research and Reviews
|September 27, 2002
PubMed
Summary

Diabetes prevalence is rising in Japan due to lifestyle changes and genetic factors. Increased sedentary behavior and fat intake, combined with specific gene variations, contribute to higher rates of hyperglycemia and cardiovascular risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypothalamic insulin resistance in type 2 diabetes is localized to the posterior hypothalamus.

JCI insight·2026
Same author

Revisiting the TSH range in older adults: associations between subclinical hypothyroidism and geriatric conditions.

Journal of the Endocrine Society·2026
Same author

Agreement and systematic difference between bioelectrical impedance analysis and dual-energy X-ray absorptiometry for appendicular lean mass in 1617 community-dwelling older adults: The Bunkyo Health Study.

Clinical nutrition ESPEN·2026
Same author

Dual action of imeglimin on insulin secretion and sensitivity in type 2 diabetes.

Diabetes, obesity & metabolism·2026
Same author

Age-related differences in bone structural parameters using 3D-DXA and TBS in men and women: The Bunkyo Health Study.

Bone·2025
Same author

Association between cognitive function and relaxation rates of the cerebral cortex.

Journal of the neurological sciences·2025

Area of Science:

  • Endocrinology
  • Genetics
  • Public Health

Background:

  • Diabetes mellitus and hyperglycemia are increasing in Japan, affecting over 12 million individuals.
  • This rise is attributed to a combination of genetic predispositions and environmental factors unique to the Japanese population.
  • Post-World War II societal shifts have led to significant changes in Japanese lifestyle and diet.

Purpose of the Study:

  • To investigate the interplay between genetic and environmental factors contributing to the escalating prevalence of diabetes in Japan.
  • To understand the role of lifestyle modifications and genetic polymorphisms in the development of insulin resistance and glucose intolerance.

Main Methods:

  • Analysis of lifestyle changes in the Japanese population, including diet and physical activity levels.
  • Examination of genetic polymorphisms in genes related to lipid and glucose metabolism (beta 3-adrenergic receptor, peroxisome proliferator-activated receptor gamma, calpain-10).
  • Assessment of the association between increased body mass index (BMI) and the development of diabetes risk factors.

Main Results:

  • Japanese men exhibit a steadily increasing BMI, a known risk factor for insulin resistance and diabetes.
  • A higher prevalence of specific gene polymorphisms (beta 3-adrenergic receptor, PPAR-gamma, calpain-10) is observed in the Japanese population.
  • The interaction between a 'thrifty' genotype and modern lifestyle changes is implicated in the rising diabetes rates.

Conclusions:

  • The increasing prevalence of diabetes in Japan is a multifactorial issue involving genetic susceptibility and environmental influences.
  • Lifestyle changes, including reduced physical activity and increased fat consumption, exacerbate diabetes risk in genetically predisposed individuals.
  • Understanding these interactions is crucial for addressing the growing burden of diabetes and associated cardiovascular risks in Japan.

Related Experiment Videos