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Updated: May 21, 2025
Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
Published on: May 27, 2020
Association between cognitive function and relaxation rates of the cerebral cortex
Satoru Kamio1, Akifumi Hagiwara2, Koji Kamagata2
1Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Objective:
We aimed to elucidate the correlation between cognitive function and relaxation rates of the cerebral cortex in the early stages of cognitive decline.
Methods:
Brain MRI was performed on 97 community-dwelling elderly participants aged 65-84 years. R1 (1/T1) and R2 (1/T2) maps were obtained with synthetic MRI (SyMRI). Cognitive function was evaluated using the Japanese version of the Montreal Cognitive Assessment (MoCA). Participants were categorized into mild cognitive impairment (n = 47) and healthy control (n = 50) groups. Voxel-based quantification (VBQ) and voxel-based morphometry (VBM) analyses were conducted using two-sample t-tests and multiple regression models, with age and sex as covariates.
Results:
VBQ revealed a significant negative correlation between R1 values and MoCA visuospatial/executive score in the bilateral frontal pole and left superior frontal gyrus (family-wise error-corrected p < 0.05). No significant correlations were found between R2 values and visuospatial/executive score. The multiple regression analysis for VBM showed no significant correlations, and the two-sample t-tests for both VBQ and VBM revealed no significant group differences.
Conclusion:
Visuospatial/executive impairment correlated with higher R1 and R2 values in the frontal cortex, suggesting their potential as biomarkers for early cognitive decline.
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