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Extraorbital giant cell angiofibroma.

K Husek¹, K Veselý

¹Department of Pathology, St. Anne's University Hospital Brno, Czech Republic. husek@fnusa.cz

Ceskoslovenska Patologie

|September 28, 2002

Summary

Giant cell angiofibroma (GCA) is a benign neoplasm that can occur outside the orbit. This case report details a GCA on the forearm, highlighting its histological features and immunohistochemical profile.

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Area of Science:

Pathology
Oncology
Dermatology

Background:

Giant cell angiofibroma (GCA) is a rare benign mesenchymal neoplasm.
Typically found in the orbit, GCA can present in extraorbital locations.

Observation:

A 47-year-old male presented with a 6 cm subcutaneous forearm tumor.
Histological examination revealed a GCA with characteristic vascular patterns and atypical cells.
Immunohistochemistry showed diffuse vimentin and CD34 expression.

Findings:

The tumor exhibited a unique histological pattern with small, hyalinized vessels and a mix of mononuclear and bizarre lesional cells.
Immunohistochemical analysis confirmed GCA, with negative staining for cytokeratins, bcl-2, desmin, actin, VWF, S100, alpha-1-antitrypsin, CD99, lysozyme, and FXIIIa.
The patient experienced no recurrence after 13 months of follow-up.

Implications:

This case expands the known anatomical distribution of giant cell angiofibroma.
It underscores the importance of considering GCA in the differential diagnosis of soft tissue tumors.
The findings support GCA as a benign entity with favorable prognosis, even in extraorbital sites.

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