Search research articles

Search research articles

Related Experiment Videos

Laser-based non-fluorescence detection techniques for liquid separation systems.

T de Beer¹, N H Velthorst, U A Th Brinkman

¹Department of Analytical Chemistry and Applied Spectroscopy, Vrije Universiteit Amsterdam, The Netherlands. tjipke.debeer@spark.nl

Journal of Chromatography. A

|September 28, 2002

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Consent and assessing capacity in perioperative and intensive care.

BJA education·2026

Same author

Discrete element analysis of the effect of particle cohesion on die filling behaviour of pharmaceutical powders in a rotary tablet press.

International journal of pharmaceutics·2026

Same author

Exploring twin-screw feeding behaviour across different loss-in-weight feeders.

International journal of pharmaceutics·2026

Same author

The effect of material properties and process parameters on die filling using double-tip tooling: A PLS-model-based analysis.

International journal of pharmaceutics·2025

Same author

The effect of material properties and process parameters on die filling at varying throughputs: A PLS-model-based analysis.

International journal of pharmaceutics·2024

Same author

Visualization of the granule temperature using thermal imaging to improve understanding of the granulation mechanism in continuous twin-screw melt granulation.

International journal of pharmaceutics·2023

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

This review explores non-fluorescence laser-based detection methods for analytical techniques like liquid chromatography (LC) and capillary electrophoresis (CE). It evaluates thermal lens spectrometry, photoacoustic detection, and Raman spectroscopy for enhanced analytical chemistry applications.

Area of Science:

Analytical Chemistry
Spectroscopy
Chromatography

Background:

Lasers have gained attention for detection in liquid chromatography (LC) and capillary electrophoresis (CE) over the past 20 years.
Laser-induced fluorescence has been the primary focus, necessitating exploration of alternative methods.

Purpose of the Study:

To review developments in non-fluorescence laser-based detection techniques for LC and CE.
To provide an overview of alternative laser detection methods beyond fluorescence.

Main Methods:

The review covers thermal lens spectrometry.
Photoacoustic detection is discussed.
Refractive index detection, including backscattering, is examined.
Raman spectroscopy and degenerate four-wave mixing are included.

Related Experiment Videos

An outline of laser characteristics is provided.

Main Results:

Developments in non-fluorescence laser detection techniques for LC and CE are presented.
The paper evaluates thermal lens spectrometry, photoacoustic detection, refractive index detection, Raman spectroscopy, and degenerate four-wave mixing.
Characteristics of lasers relevant to these techniques are outlined.

Conclusions:

The review provides an overall evaluation of the discussed non-fluorescence laser detection techniques.
Future perspectives for these methods in LC and CE are discussed.