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Urine nandrolone metabolites: false positive doping test?
1MRC/UCT Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Sports Science Institute of South Africa, Newlands, South Africa.
British Journal of Sports Medicine
|September 28, 2002
Summary
This review examines nandrolone metabolism studies. It investigates if athletes can test positive for nandrolone without direct administration, exploring potential endogenous or exogenous sources.
Area of Science:
- Pharmacology
- Biochemistry
- Sports Science
Background:
- Nandrolone is an anabolic-androgenic steroid.
- Detection of nandrolone and its metabolites is crucial in anti-doping efforts.
- Understanding nandrolone metabolism is key to interpreting analytical results.
Purpose of the Study:
- To review existing literature on nandrolone metabolism.
- To assess the scientific evidence for nandrolone detection without direct administration.
- To determine the feasibility of non-intentional nandrolone positive tests.
Main Methods:
- Literature search of scientific databases.
- Analysis of studies on nandrolone pharmacokinetics and metabolism.
- Evaluation of reported nandrolone metabolite concentrations.
Main Results:
- Several studies indicate that certain foods or supplements may contain nandrolone precursors.
- Endogenous production of nandrolone or related compounds is generally considered negligible.
- Metabolism of other substances can lead to nandrolone or its metabolites.
Conclusions:
- It is theoretically possible to test positive for nandrolone without direct ingestion or injection.
- Further research is needed to quantify the risk of non-intentional nandrolone detection.
- Analytical methods must be sensitive enough to distinguish between intentional and unintentional exposure.