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Low plasma adiponectin concentrations do not predict weight gain in humans
Barbora Vozarova1, Norbert Stefan, Robert S Lindsay
1National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA. bvozarov@mail.nih.gov
Diabetes
|September 28, 2002
Summary
Low plasma adiponectin levels do not predict future weight gain in Pima Indians, suggesting hypoadiponectinemia is not a cause of obesity. The link between adiponectin and type 2 diabetes is likely due to other factors.
Area of Science:
- Endocrinology
- Metabolic Health
- Obesity Research
Background:
- Low plasma adiponectin concentrations are linked to obesity and predict type 2 diabetes.
- Rodent studies suggest adiponectin deficiency may contribute to weight gain.
Purpose of the Study:
- To prospectively investigate if low plasma adiponectin predicts weight gain in Pima Indians.
- To clarify the role of adiponectin in obesity development and its predictive effect on type 2 diabetes.
Main Methods:
- Measured plasma adiponectin in 219 nondiabetic Pima Indians.
- Assessed body weight and BMI at baseline and follow-up.
- Analyzed the association between baseline adiponectin and subsequent weight/BMI changes.
Main Results:
- Plasma adiponectin was cross-sectionally associated with lower body weight.
- Prospectively, baseline adiponectin did not predict changes in weight or BMI.
- These findings held after adjusting for follow-up time, age, and sex.
Conclusions:
- Low plasma adiponectin concentrations do not appear to be an etiologic factor in obesity development among Pima Indians.
- The predictive effect of low adiponectin on type 2 diabetes risk is likely mediated by factors other than increased adiposity.