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Related Experiment Videos

Autonomic neuropathies.

Phillip A Low1

  • 1Department of Neurology, Mayo Medical School, Mayo Clinic, Rochester, Minnesota 55905, USA. low@mayo.edu

Current Opinion in Neurology
|September 28, 2002
PubMed
Summary
This summary is machine-generated.

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Recent advances in autonomic neuropathies show autoantibodies aiding diagnosis and treatment. New insights into diabetic neuropathy, hereditary forms, and treatments for orthostatic hypotension and hyperhidrosis are highlighted.

Area of Science:

  • Neurology
  • Autonomic Nervous System Disorders

Background:

  • Autonomic neuropathies encompass a range of conditions affecting the autonomic nervous system.
  • Understanding their pathogenesis and pathophysiology is crucial for effective management.

Purpose of the Study:

  • To provide an updated review of recent advances in the pathogenesis, pathophysiology, and treatment of select autonomic neuropathies.
  • To highlight key diagnostic and therapeutic developments.

Main Methods:

  • Review of recent literature on autonomic neuropathies.
  • Analysis of diagnostic markers, genetic mutations, and treatment strategies.

Main Results:

  • Autoantibodies, such as ganglionic antibody, are important in diagnosing and managing subacute autonomic neuropathy and may indicate occult neoplasms.
Keywords:
Non-programmatic

Related Experiment Videos

  • Diabetic neuropathy involves autonomic failure, with sildenafil effective for erectile dysfunction and sympathetic cardiac hyperinnervation a potential concern.
  • Gene mutations for hereditary sensory and autonomic neuropathies (HSAN) I, III, and IV are identified, showing unmyelinated fiber loss.
  • Erythropoietin and water show promise for orthostatic hypotension, while botulinum toxin is effective for hyperhidrosis.

    • Conclusions:

    • Ganglionic antibodies are implicated in autoimmune autonomic neuropathy.
    • Sympathetic cardiac hyperinnervation may lead to arrhythmias and sudden death.
    • Genetic knowledge of HSAN I, III, and IV improves diagnosis.
    • Botulinum toxin offers effective treatment for hyperhidrosis, and novel approaches exist for orthostatic hypotension.