Related Experiment Video
Updated: Sep 29, 2026

Immunohistochemical and Calcium Imaging Methods in Wholemount Rat Retina
Published on: October 13, 2014
Glycine receptors and transporters on bullfrog retinal Müller cells
Jiu-Lin Du1, Li-Ya Xu, Xiong-Li Yang
1Institute of Neurobiology, Fudan University, 220 Han-Dan Road, Shanghai 200433, China.
Abstract:
Glycine is a principal inhibitory neurotransmitter in the vertebrate retina. We have characterized glycine-induced currents from Müller cells in the bullfrog retinal slice preparation using whole-cell recordings. The glycine-induced current was partially suppressed by strychnine, and the remaining strychnine-resistant component was sacrosine-sensititve, suggesting that these two components may be mediated by glycine receptors and glycine transporters, respectively. Furthermore, the two components were maximal at the inner nuclear layer (INL) and declined asymmetrically as the application site was moved away from the INL to either the external or internal limiting membranes. It is suggested that Müller cells may be involved in glycinergic transmission by communicating with retinal neurons through these receptors and transporters.
Related Concept Videos
G-Protein Gated Ion Channels
Sensory organs,...
G Protein-coupled Receptors
Cholinergic Receptors: Muscarinic
The subtypes M1, M3, and M5 couple with the Gq subunit and activate the phospholipase C (PLC) activity, mobilizing intracellular Ca2+. Activation...
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:

