Related Experiment Videos
Injectable agents: present and future
Deborah J Lightner1, Nancy B Itano, Susan D Sweat
1Department of Urology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. lightner.deborah@mayo.edu
Current Urology Reports
|October 2, 2002
Summary
Minimally invasive bulking agents offer a safe and effective treatment for stress urinary incontinence (SUI) when conservative methods fail. Newer agents show promise for long-term durability and improved therapeutic options for women with SUI.
Area of Science:
- Urology
- Gynecology
- Biomaterials Science
Background:
- Stress urinary incontinence (SUI) is a prevalent condition often managed conservatively.
- Failure of conservative strategies necessitates exploring effective, safe, and durable minimally invasive treatments.
- Current treatments aim to reduce medical costs associated with SUI management.
Purpose of the Study:
- To review current basic science and clinical research on newer agents for soft-tissue bulking in SUI treatment.
- To evaluate the efficacy and durability of existing and emerging bulking agents.
- To explore new therapeutic options for women suffering from SUI.
Main Methods:
- Review of existing literature on bulking agents for SUI.
- Analysis of basic science research on material development.
- Evaluation of clinical data on efficacy and safety of minimally invasive SUI treatments.
Main Results:
- Injection of available bulking agents is a safe, minimally invasive procedure with demonstrated efficacy.
- Success rates for bulking agents in anatomic SUI are comparable to those in intrinsic sphincter deficiency.
- Long-term durability of several current agents requires further investigation.
Conclusions:
- Minimally invasive bulking agents represent a viable treatment option for SUI.
- Further research is needed to establish the long-term durability of newer agents.
- Bulking agents offer expanded therapeutic possibilities for women with SUI.