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Interferons as antiangiogenic agents
1Taussig Cancer Center, The Cleveland Clinic Foundation, R40, 9500 Euclid Avenue, Cleveland, OH 44195, USA. lindned@cc.ccf.org
Current Oncology Reports
|October 2, 2002
Abstract:
Interferons (IFNs), pleiotropic cytokines that regulate antiviral, antitumor, apoptotic, and cellular immune responses, were the first endogenous antiangiogenic regulators identified. In a species-specific manner, IFNs inhibit secretion of such angiogenic factors as basic fibroblast growth factor from tumor cells. The antiangiogenic activity of IFNs is enhanced when they are combined with other antiangiogenic agents, such as tamoxifen and thalidomide.