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[Arterial hypertension in elderly individuals]
1Service de Médecine interne, Université de Bologne, Italie.
Presse Medicale (Paris, France : 1983)
|October 3, 2002
Summary
Indapamide SR, amlodipine, and hydrochlorothiazide showed similar blood pressure lowering effects in elderly patients. Indapamide SR demonstrated a higher normalization rate for elevated systolic-diastolic and systolic pressures.
Area of Science:
- Cardiology
- Geriatrics
- Pharmacology
Background:
- Hypertension is a prevalent condition in elderly populations.
- Effective antihypertensive management is crucial for reducing cardiovascular risk in older adults.
Purpose of the Study:
- To compare the antihypertensive efficacy of indapamide SR, amlodipine, and hydrochlorothiazide in elderly patients.
- To assess the normalization rates of blood pressure in different treatment groups.
Main Methods:
- Multicenter, randomized, double-blind European study involving 524 elderly patients (mean age 72 years).
- Three parallel treatment arms: indapamide SR 1.5 mg, amlodipine 5 mg, and hydrochlorothiazide 25 mg.
- Mean reduction in diastolic blood pressure was measured.
Main Results:
- All three treatment arms demonstrated equivalent antihypertensive effects.
- A mean reduction of 23 mmHg in diastolic blood pressure was observed across groups.
- Indapamide SR group showed a higher rate of blood pressure normalization for both elevated systolic-diastolic and isolated systolic hypertension.
Conclusions:
- Indapamide SR, amlodipine, and hydrochlorothiazide are effective in lowering blood pressure in elderly hypertensive patients.
- Indapamide SR may offer an advantage in achieving blood pressure normalization.
- Further research, like the ongoing HYVET study, is evaluating indapamide SR in very elderly patients.