Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Conjugate vaccines].

B Swennen1, J Sternon

  • 1Unité d'Epidémiologie pédiatrique et Vaccination, Ecole de Santé publique, U.L.B.

Journal De Pharmacie De Belgique
|October 3, 2002
PubMed
Summary
This summary is machine-generated.

Conjugate vaccines provide crucial protection for young children against serious infections like Haemophilus influenzae type b and pneumococcal disease. This review examines their effectiveness, focusing on immune response, protection surrogates, and herd immunity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High number of hospitalisations and non-classical presentations: lessons learned from a measles outbreak in 2017, Belgium.

Epidemiology and infection·2020
Same author

Traitement Des Infections Bronchopulmonaires Aigues Par Le Laurylsulfate De Tetracycline Intra-Musculaire.

Acta clinica Belgica·2016
Same author

[Determinants of breastfeeding in the Brussels Region].

Revue medicale de Bruxelles·2015
Same author

Breastfeeding duration: a survival analysis-data from a regional immunization survey.

BioMed research international·2014
Same author

[Breastfeeding in the French-speaking community of Belgium (2009)].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2014
Same author

[Vaccination: cost-effectiveness ratio].

Revue medicale de Bruxelles·2009
Same journal

[Evaluation of preoperative nutritional status in visceral surgery Correlational study].

Journal de pharmacie de Belgique·2018
Same journal

[Biosimilars, no generic biologicals!].

Journal de pharmacie de Belgique·2018
Same journal

[Drug-drug interactions with risk of QT-prolongation. A epidemiological study in Belgian community pharmacies].

Journal de pharmacie de Belgique·2018
Same journal

[Medication screening by the community pharmacist in Belgium].

Journal de pharmacie de Belgique·2018
Same journal

[Frequency and nature of drug related problems with corticosteroids in Belgian community pharmacies].

Journal de pharmacie de Belgique·2018
Same journal

[A practical program for outpatient parenteral antimicrobial therapy].

Journal de pharmacie de Belgique·2018
See all related articles

Area of Science:

  • Immunology
  • Vaccinology
  • Pediatric Infectious Diseases

Context:

  • Conjugate vaccines have revolutionized pediatric immunization, extending protection to diseases previously difficult to prevent in infants.
  • These vaccines convert T-independent antigens into T-dependent ones, enabling immune responses in children under two years old.

Purpose:

  • To review the efficacy and immunological principles of three key conjugate vaccines.
  • To address critical questions regarding antigen interference, serological correlates of protection, herd immunity, and serotype replacement.

Summary:

  • Conjugating capsular polysaccharides to carrier proteins enhances immunogenicity, providing protection against Haemophilus influenzae type b, Neisseria meningitidis serogroup C, and Streptococcus pneumoniae.
  • The review explores challenges such as antigenic interference and discusses the concept of serological surrogates for vaccine efficacy.

Related Experiment Videos

  • It also examines the broader public health implications, including herd immunity and the potential for serotype replacement.

    • Impact:

    • Conjugate vaccines significantly reduce the burden of invasive bacterial infections in children, improving child survival rates.
    • Understanding immune responses and epidemiological effects is vital for optimizing vaccination strategies and combating infectious diseases.