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An enantioselective synthetic pathway towards plakortones
1Department of Chemistry, Institute of Chinese Medicine, Central Laboratory of the Institute of Molecular Technology for Drug Discovery and Synthesis, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
Chemical Communications (Cambridge, England)
|October 3, 2002
Abstract:
An enantioselective synthesis of functionalized bicyclic lactones 2, 3 and 4, core structures of plakortones, are described; the configurations of 2, 3 and 4 were confirmed by X-ray crystallographic analyses of their precursors 11, 19 and 24, respectively.