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[Changes in the gonads and reproductive capacity of white rats after oral maneb poisoning]
Abstract:
Changes in the gonads and reproduction capacity of white rats following oral intoxication with maneb are studied. The preparation at doses 1/10, 1/50, 1/100 and 1/5000 LD50 is administered to the starting generation of white rats twice weekly. Changes in the gonads--biochemical, histological, histoenzymatic and electron microscopic--are established, as well as a capacity for reproduction of the starting I and II offspring. The results show a clearcut gonadotropic effect of the preparation, manifested by morphological changes in the starting generation, and by changes in fertility, gestation, survival and lactation of the starting I and II offspring.
Insights
Maneb exposure in white rats caused significant changes in reproductive organs and capacity. Offspring fertility, gestation, survival, and lactation were negatively impacted by maneb intoxication.
Area of Science:
- Toxicology
- Reproductive Biology
- Histopathology
Context:
- Investigating the toxicological effects of maneb, a widely used fungicide.
- Assessing the impact of pesticide exposure on mammalian reproductive systems.
Purpose:
- To determine the effects of oral maneb intoxication on the gonads and reproductive capacity of white rats.
- To evaluate the biochemical, histological, and functional changes in reproductive organs and offspring.
Summary:
- White rats were administered varying doses of maneb (1/10 to 1/5000 LD50) orally, twice weekly.
- Morphological and biochemical changes in the gonads of the parent generation were observed.
- Reproductive parameters including fertility, gestation, survival, and lactation in the first and second offspring generations were significantly altered.
Impact:
- Maneb exhibits a clear gonadotropic effect, impacting reproductive health across generations.
- Findings highlight potential risks of maneb exposure to mammalian reproductive systems.
- Results inform risk assessment for pesticides and reproductive toxicology studies.