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Updated: Sep 29, 2026

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
Published on: May 16, 2016
Possible participation of endotoxin of gram-negative bacteria in pathogenesis of liver damage during viral hepatitis
1Kazan State Medical University.
Abstract:
Possible role of gram-negative bacteria in the genesis of hepatic damage during chronic viral hepatitis B and C was studied. Histological activity, hepatocyte proliferative activity, and expression of alpha-smooth muscle actin were compared with the severity of endotoxemia in patients with chronic hepatitis B and C. The study revealed a correlation between the degree of intralobular necroses, hepatocyte proliferation, and myofibroblast transdifferentiation of Ito cells with endotoxin concentration in the blood.
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