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Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
Published on: May 16, 2016
Systemic endotoxemia during chronic viral hepatitis
1Kazan State Medical University. uchast@kgmu.ru
Abstract:
Incidence and severity of systemic endotoxemia in patients with chronic viral hepatitis B and C were studied using the limulus test. Healthy subjects and patients with acute viral hepatitis B and C comprised reference groups. The incidence of "physiological" systemic endotoxemia in healthy subjects was 31.3%, while in chronic hepatitis systemic endotoxemia was found in 69-84% patients and it was more severe in this case. A significant correlation was revealed between systemic endotoxemia with virus replication and the degree of basic clinical and laboratory signs in patients with chronic viral hepatitis B.
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