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[Immunological aging]
1Inserm U25, hôpital Necker, 161, rue de Sèvres, 75015 Paris, France. bach@necker.fr
Comptes Rendus Biologies
|October 4, 2002
Abstract:
Immune responses decline with age, as assessed by the increasing role of infections in elderly subjects. This decline is, however, very progressive, and usually only clear-cut after 80 years of age. Major difficulties have been encountered to delineate the cellular basis of this immunodeficiency, which is subtle and inconsistent, at the origin of contradictory reports. This is, however, an important challenge in view of the possible therapeutic perspectives of immunotherapy of aged subjects.