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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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NCBI genetic resources supporting immunogenetic research.

M Feolo1, W Helmberg, S Sherry

  • 1The National Center for Biotechnology Information, Bethesda, MD 20894, USA. feolo@ncbi.nlm.nih.gov

Reviews in Immunogenetics
|October 4, 2002
PubMed
Summary

The National Center for Biotechnology Information (NCBI) offers integrated databases for biological information retrieval. These resources facilitate discovery by linking diverse data types, including sequences and literature, for researchers.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • The National Center for Biotechnology Information (NCBI) provides integrated database resources.
  • These resources aim to enhance information retrieval and the discovery of novel biological relationships.
  • Data is categorized by content type (bibliographic, sequence, structure, map) and curation level.

Purpose of the Study:

  • To describe the integrated database resources created and maintained by the NCBI.
  • To highlight the multi-dimensional search capabilities and data linking.
  • To introduce the emerging dbMHC resource for Major Histocompatibility Complex (MHC) data.

Main Methods:

  • Categorization of data by primary content (text, sequence, structure, map) and expert curation levels.
  • Implementation of multi-dimensional search strategies (keyword, sequence, map coordinates).
  • Development of bi-directional links between related data objects.

Main Results:

  • NCBI resources enable efficient retrieval of information through diverse entry points.
  • Connections between bibliographic, sequence, map, and structure data facilitate relationship discovery.
  • The dbMHC resource is emerging to present MHC data in collaboration with the IHWG.

Conclusions:

  • NCBI's integrated databases significantly improve access to and discovery of biological information.
  • The linking of diverse data types supports research across genetics, molecular biology, and clinical considerations.
  • Emerging resources like dbMHC further augment the NCBI's contribution to specific research areas.