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Space flight and oxidative stress.

T P Stein1

  • 1Department of Surgery, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford, New Jersey 08084, USA. tpstein@umdnj.edu

Nutrition (Burbank, Los Angeles County, Calif.)
|October 4, 2002
PubMed
Summary
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Space flight elevates oxidative stress, impacting lipids and DNA for weeks post-landing. Increasing dietary antioxidants may mitigate these harmful effects.

Area of Science:

  • Space medicine
  • Human physiology
  • Biochemistry

Background:

  • Space flight induces oxidative stress, particularly after long durations.
  • This stress persists for weeks upon return to Earth's gravity.
  • Biomarkers indicate damage to lipids and DNA.

Purpose of the Study:

  • To investigate the physiological effects of space flight on oxidative stress.
  • To identify biomarkers of oxidative damage post-flight.
  • To explore potential mitigation strategies for post-flight oxidative stress.

Main Methods:

  • Analysis of human blood and urine samples for oxidative stress markers.
  • Comparison of human data with rodent models.
  • Assessment of lipid peroxidation and antioxidant levels.
Keywords:
NASA Discipline Regulatory PhysiologyNon-NASA Center

Related Experiment Videos

Main Results:

  • Increased lipid peroxidation and DNA damage markers (8-iso-prostaglandin F(2alpha), 8-oxo-7,8 dihydro-2 deoxyguanosine) observed post-flight.
  • Reduced levels of certain blood antioxidants.
  • Rodent studies corroborated increased oxidative stress and decreased antioxidant enzyme activity post-flight.

Conclusions:

  • Space flight significantly increases oxidative stress, affecting lipids and DNA.
  • Energy deficiency and metabolic changes during recovery contribute to this stress.
  • Enhanced dietary antioxidant intake may reduce the severity of post-flight oxidative stress.