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Updated: Sep 29, 2026
A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis (ALS)
Published on: February 21, 2011
Evidence for the validity and reliability of the ALS assessment questionnaire: the ALSAQ-40
C Jenkinson1, R Fitzpatrick, C Brennan
1Health Services Research Unit, Division of Public Health & Primary Health Care, University of Oxford, Institute of Health Sciences, Headington, Oxford, OX3 7LF, UK.
Objectives:
The purpose of the study was to assess the validity and reliability of a new disease specific measure of health-related quality of life for ALS/MND: the 40-item ALS Assessment Questionnaire (ALSAQ-40).
Design:
We carried out a longitudinal postal survey. The two administrations of the questionnaire were separated by 3 months.
Sample:
Subjects were patients diagnosed with ALS/MND and registered with the UK MND Association.
Results:
Dimensions of the ALSAQ-40 were shown to have high levels of internal reliability. The ALSAQ-40 was found to be sensitive to changes in self reported overall health state.
Conclusion:
We concluded that the ALSAQ-40 has high levels of reliability and validity and can be used as an outcome measure in studies evaluating new treatment regimes and therapies.
