Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statins and renal function.

Moses Elisaf1, Dimitri P Mikhailidis

  • 1Department of Internal Medicine, Medical School, University of Ioannina, Greece.

Angiology
|October 9, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of fibrate treatment in dyslipidemia: an overview.

Current pharmaceutical design·2013
Same author

Ezetimibe therapy for dyslipidemia: an update.

Current pharmaceutical design·2013
Same author

Colesevelam: a new and improved bile acid sequestrant?

Current pharmaceutical design·2013
Same author

Hydrochlorothiazide vs. chlorthalidone as the optimal diuretic for the management of hypertension.

Current pharmaceutical design·2013
Same author

PCSK9 inhibition - a novel mechanism to treat lipid disorders?

Current pharmaceutical design·2013
Same author

Combined dyslipidemia: should the focus be LDL cholesterol or atherogenic dyslipidemia?

Current pharmaceutical design·2013
Same journal

Refining Phenotype-Based Interpretation of SGLT2 Inhibitors After AMI Without Heart Failure.

Angiology·2026
Same journal

Response to: "Integrating Noninvasive Liver Indices into Risk Stratification of Myocardial Infarction With Non-Obstructive Coronary Arteries".

Angiology·2026
Same journal

Response to: "Beyond Traditional Risk Markers: Is FIB-4 Sufficient in MINOCA?"

Angiology·2026
Same journal

Letter: Further Considerations on the Clinical Use of the Scottish Inflammatory Prognostic Score in STEMI No-Reflow Prediction.

Angiology·2026
Same journal

Contextualizing Remodeling Endpoints in Endovascular Treatment for Symptomatic SISMAD.

Angiology·2026
Same journal

<i>Response to the Letter to the Editor</i>: "Effect of Invasive Hemodynamic Monitoring on the Outcomes of Cardiogenic Shock in Patients With Acute Myocardial Infarction".

Angiology·2026
See all related articles

Statins may offer benefits for patients with renal disease, potentially improving kidney function and reducing vascular risks. Further research is crucial to establish their role and optimal use in this high-risk population.

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Renal disease elevates vascular event and atherosclerosis risk due to factors like dyslipidemia, hypertension, and diabetes.
  • Impaired renal function itself is an independent predictor of vascular risk.
  • Established risk factors and other predictors like homocysteine and lipoprotein(a) are often elevated in renal disease patients.

Purpose of the Study:

  • To review existing evidence on the beneficial effects of statins in patients with various renal diseases.
  • To explore potential mechanisms by which statins may improve renal outcomes and cardiovascular health.
  • To consider drug interactions and pharmacokinetic changes relevant to statin use in impaired renal function.

Main Methods:

  • Review of experimental and clinical evidence regarding statin use in renal disease.

Related Experiment Videos

  • Analysis of studies examining statin effects on renal function, proteinuria, and blood pressure.
  • Consideration of pharmacokinetic data and drug interactions.

    • Main Results:

    • Statins show potential benefits including improved renal function and decreased microalbuminuria.
    • Evidence suggests statins may lower blood pressure and improve renal allograft survival.
    • Mechanisms of action and interactions with common comorbidities are discussed.

    Conclusions:

    • Statins may offer significant benefits for patients with renal disease, impacting both renal and cardiovascular outcomes.
    • Further investigation is urgently needed to define the role of statins in this population.
    • Determining the optimal statin and managing potential drug interactions are critical next steps.