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False-reactive test for hepatitis B surface antigen following administration of granulocyte-colony-stimulating factor
1Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
Background And Objective:
High-dose granulocyte transfusions are being administered to severely granulocytopenic patients. A single dose of G-CSF is given to donors for mobilization of granulocytes prior to donation.
Materials And Methods:
Infectious disease tests were performed on a donor before and after G-CSF was given.
Results:
Hepatitis B surface antigen (HBsAg) testing was transiently reactive following administration of G-CSF when examined using a test kit from one manufacturer, but not another. No other cause was found.
Conclusion:
A false-reactive test for HBsAg using one manufacturer's test kit can occur following a single dose of G-CSF.
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