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[Na transport in the cochlea of mammals]
V Couloigner1, O Sterkers, E Ferrary
1INSERM U.426 et EMI-U 0112, Faculté Xavier Bichat, Université Paris 7, Paris.
Abstract:
Endolymph, the fluid that bathes the apical side of the inner ear sensory cells, is a K-rich and Na-poor fluid. In the cochlea, various epithelial transport systems involved in the transport of Na from the apical endolymphatic to the basolateral perilymphatic compartments have been identified: basolateral Na+, K(+)-ATPase, apical non selective cationic channels, Na+/H+ exchanger, and ENaC epithelial Na channel. These transporters may be involved in physiological and pathological processes in which endolymph Na concentration is high.
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