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Effects of stereochemistry of sugars on protein stabilities
Kiyonari Masumoto1, Tadashi Ueda, Makiko Nagata
1Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Protein and Peptide Letters
|October 9, 2002
Abstract:
We investigated thermal stabilities of four proteins in the presence of four kinds of sugars to analyze the mechanism of stabilization of proteins by additives. These proteins were stabilized by the addition of sugars, and the degree of stabilization correlated to the partial molar isentropic compressibility of the sugar.