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Tubulin as an antiprotozoal drug target
1Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, 332 Lloyd M Parks Hall, 500 West 12th Avenue, Columbus, OH 43210, USA. werbovetz.1@osu.edu
Mini Reviews in Medicinal Chemistry
|October 9, 2002
Abstract:
Since tubulin is a known anticancer and anthelmintic drug target, the investigation of protozoal tubulin could lead to the development of new antiparasitic drugs. This review outlines the current state of knowledge concerning drug-mammalian tubulin interactions, the effects of antimicrotubule agents on parasites and parasite tubulin, and our current hypotheses regarding the development of selective ligands for protozoal tubulin as antiparasitic drug candidates.